March 16, 2018

Read e-book online Adaptive Dynamics of Infectious Diseases: In Pursuit of PDF

By Ulf Dieckmann, Johan A. J. Metz, Maurice W. Sabelis, Karl Sigmund

ISBN-10: 0511525729

ISBN-13: 9780511525728

ISBN-10: 0521022134

ISBN-13: 9780521022132

ISBN-10: 0521781655

ISBN-13: 9780521781657

This monograph takes inventory of our present wisdom at the evolutionary ecology of infectious ailments, and units out the pursuits for the administration of virulent pathogens. through the textual content, the basic techniques and strategies underlying the types are conscientiously defined in a special sequence of built-in packing containers.

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Additional info for Adaptive Dynamics of Infectious Diseases: In Pursuit of Virulence Management

Sample text

1, if we effectively vaccinate a fraction p of the instream of newborns B, we decrease R0 by a fraction p. Therefore, to eradicate a disease through vaccination an effective vaccination coverage of p > 1 − 1/R0 is required. In models that exclude within-host interactions between disease strains (as results from multiple infections or when recovery does not result in full immunity), R0 can serve as a convenient yardstick to assess the evolutionary dynamics of a disease: strains with a higher R0 outcompete strains with a lower R 0 .

In humans they typically cause diarrhea and can be transmitted by alternative modes: directly (person-to-person) or indirectly (person-to-food-to-person). No Cholera Sit-and-wait Propagules are shed into the environment where they remain until picked up by another host. Their greater durability in the external environment distinguishes them from directly transmitted pathogens. No Smallpox Attendantborne Propagules are picked up by No attendants, generally on hands, and transmitted to susceptible hosts without infecting the attendants.

We assume that the transmission coefficient β first rises as a function of α because increased host exploitation increases both α and the probability of infection per contacted host (a component of β), thus making increased virulence beneficial when virulence is low. We incorporate a cost of host immobility on direct transmission by assuming that the transmission coefficient β eventually declines as a function of α. , through susceptible hosts caring for or visiting the immobilized patient). A derivation of the relation between β and α from first principles is very complicated and is therefore beyond the scope of this chapter.

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Adaptive Dynamics of Infectious Diseases: In Pursuit of Virulence Management by Ulf Dieckmann, Johan A. J. Metz, Maurice W. Sabelis, Karl Sigmund

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