March 15, 2018

Alternatives to Animal Testing by R. E. Hester, R. M. Harrison PDF

By R. E. Hester, R. M. Harrison

ISBN-10: 0854042113

ISBN-13: 9780854042111

Animal experimentation has lengthy been a debatable factor, with impassioned arguments on each side of the talk. more and more it has turn into extra expedient and possible to increase new tools that keep away from using animals. there's contract on either side that relief and refinement of experiments on animals can be a huge target for the industries involved.

Alternatives to Animal trying out, written by way of top specialists within the box, discusses the problems concerned and techniques that may be taken. subject matters comprise: the security evaluate of chemical substances; overseas validation and limitations to the validation of different checks; in vitro checking out for endocrine disruptors; clever methods to protection overview of chemical substances; substitute exams and the regulatory framework.

The publication offers an up to date dialogue of the present country of improvement of possible choices to animal trying out and is perfect for execs and teachers within the box. it is going to even be of use for graduate scholars wishing to pursue a profession within the pharmaceutical and cosmetics industries.

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This process also includes the mechanisms of independent assortment and distribution of maternal and paternal chromosomes to the progeny, as well as chromosome recombination (crossing over). See Strickbergerl l for a more detailed discussion of these events. Independent assortment of chromosomes and genetic recombination are two parameters of meiosis important in the randomization of genes before they are packaged as gametes (sperm or ova). Genetic recombination normally occurs during meiosis and involves reciprocal exchanges between chromosomes of a homologous pair adding to the randomization of genes on chromosomes during gametogenesis.

8). Inherent variation in repair capacity between organisms can lead to differential susceptibility to genotoxic effects. Hart and Setlow reported on the correlation between DNA excision repair capability and life span in several mammalian species28 : there appears to be increased repair in species with longer life spans. This relationship could well play an important role in the extrapolation of genetic effects, since most risk assessment models employ a conservative approach and assume a similar response for both rodents and humans.

Agents demonstrated only to induce DNA strand breakage, SeE or DNA adduct formation, for example, should not be viewed with the same genetic hazard potential as agents established as gene or chromosomal mutagens until the definitive tests have been conducted. 6 Basic Categories of Genetic Assays and Some Exampless Gene mutation Bacteria forward and reverse mutation Amesl Salmonella Escherichia coli: WP2 uvrAEscherichia coli: K12 forward mutation Yeast forward and reverse mutation In vitro mammalian cell forward mutation Mouse lymphoma TK assay CHOHGPRT assay V79 HGPRT assay Drosophila: SLRL Chromosome aberration In vitro cytogenetics Mouse bone marrow Mouse micronucleus Drosophila: X and Y loss Drosophila: dominant lethal Drosophila: heritable translocation Mouse: dominant lethal Rat: dominant lethal Mouse: heritable translocation Primary DNA damage Oncogenic transformation Escherichia coli: polA + IpolAassay Bacillus subtilis: rec + Irec - assay Yeast D3 , D4 , Ds , or D, somatic recombination UDS WI-38 cells Rat primary hepatocytes SCE analysis In vitro cell transformation: BALB/c 3T3 cells SHE cells Mouse lOT'h cells Mouse: somatic mutation test (spot test) Specific locus assay in mice • SHE, Syrian hamster embryo.

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Alternatives to Animal Testing by R. E. Hester, R. M. Harrison


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