By J.W. Gorrod, P. Jacob III
This ebook presents for the 1st time a unmarried complete resource of knowledge at the analytical chemistry of nicotine and comparable alkaloids. The editors have introduced jointly scientists from academia and the tobacco to explain the state of the art of the chemistry and analytical equipment for dimension of nicotine. either the scope and aspect of the publication are notable. Chapters describe the historical past, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and different alkaloids within the tobacco plant, the overall chemistry of nicotine and the analytical methodologies which have been used to degree nicotine and similar alkaloids in organic specimens, in tobacco and pharmaceutical items and in tobacco smoke. there's additionally a accomplished overview of the chemistry and toxicology of nicotine-derived nitrosamines, a big classification of tobacco cancer causing agents.
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Extra info for Analytical Determination of Nicotine and Related Compounds and their Metabolites
11 Tso TC, McMurtrey JE. Mineral deficiency and organic constituents in tobacco plants. II Amino acids. , 1960: 35; 865-870. 12 Fannin FF, Bush LP. Manipulation of alkaloid biosynthesis in detached tobacco roots by diamine and nicotinic acid feeding. Tob. Chem. Res. , 1982: 46; 32. 13 Miller RD, Collins GB, Davis DL. Effects on nicotine precursors on nicotine content in callus cultures of burley tobacco alkaloid lines. , 1983: 23; 561-565. 14 Phillips GC, Eggett BC, Collins GB. Effects of polyamine metabolic inhibitors on growth and alkaloid accumulation in tobacco callus cultures.
Oligogalacturonides prevent rhizogenesis in rolB-transformed tobacco explants by inhibiting auxin-induced expression of the rolB gene. Plant Cell, 1996: 8; 477-487. 64 Filippini F, Rossi V, Marin O, Trovato M, Costantino P, Downey P, Lo Schiavo F, Terzi M. A plant oncogene as a phosphatase. Nature, 1996: 379; 499-500. 65 Estruch JJ, Chriqui D, Grossmann K, Schell J, Spena A. The plant oncogene rolC is responsible for the release of cytokinins from glucoside conjugates. , 1991: 10; 2889-2895. , Sandberg G.
However, when shooty teratoma cells were co-cultivated with hairy root cells, nicotine was transferred through the medium to the former from the latter, where it was accumulated and converted to nornicotine. Plants regenerated from cultures transformed with wild-type Ri plasmid accumulated about twice as much nicotine, and many-fold more nornicotine, t h a n did leaves of untransformed plants. Nicotiana tabacum cv. Xanthi leaf sections were transformed with individual rol genes from TL-Ri-DNA, through the agency of A.
Analytical Determination of Nicotine and Related Compounds and their Metabolites by J.W. Gorrod, P. Jacob III
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